Svensk Juristpartner HB bedriver sedan våren 2006 juridisk rådgivning via sin webbplats. Där kan allmänheten ställa frågor om juridik och få dem besvarade av ett antal juriststudenter. Alla frågor publiceras sedan anonymt på webbplatsen så att fler personer än frågeställaren kan ta del av informationen. Då mängden inkomna frågor ökat markant, har behovet av en mer avancerad webbplats växt fram. Uppgiften har varit att skapa en ny webbplats åt Juristpartner. Genom att införa kopplingar till en databas har hanteringen av frågor och svar förbättrats. Det har även skapat möjligheten att införa nya funktioner, som sökning och kategorisering av frågorna. De språk som använts är HTML, CSS, JavaScript, PHP och SQL. Rapporten beskriver först några grundläggande begrepp inom webbutveckling, samt de olika språk och programvaror som använts. Sedan följer en genomgång av det praktiska arbetet med webbplatsen, där vissa utvalda delar även förklaras med kodexempel. Examensarbetet har resulterat i en webbplats som har bättre funktionalitet jämfört med den tidigare webbplatsen. Administreringen av webbplatsens innehåll kan nu skötas mer effektivt samtidigt som det blivit enklare för besökare att hitta på sidan. Webbplatsen finns att beskåda på http://www.juristpartner.se. / Svensk Juristpartner HB is since the spring of 2006 providing legal advice through its website. From there, the general public may ask questions regarding law and have them answered by law students. All the questions will also be posted anonymously on the website to allow more people to take part of the information. As the number of questions have increased, the need for a more advanced website has arisen. The task has been to create a new website for Juristpartner. By introducing connections to a database the ability to provide faster handling of questions and answers has improved. It has also introduced new features such as search functions and categorization of the questions. The languages used are HTML, CSS, JavaScript, PHP and SQL. This report first describes the basic concepts of web development, as well as the different languages and software that has been used. It then proceeds to explain the practical work with the website, with some chosen parts demonstrated by code examples. The degree thesis has resulted in a website that has better functionality compared to the previous website. The administration of the website’s contents can now be handled more effectively as well as making it easier for visitors to navigate the website. The website can be found at http://www.juristpartner.se.

Σκοπός την εργασίας είναι η δημιουργία ενός ολοκληρωμένου ηλεκτρονικού καταστήματος το οποίο θα παρέχει στους χρήστες μεταξύ άλλων, δυνατότητα χωρικής αναζήτησης προϊόντων, και προσωποποίησης. Η εφαρμογή υποστηρίζει όλες τις λειτουργίες ενός σύγχρονου ηλεκτρονικού καταστήματος προσθέτοντας σε αυτές ένα πλήθος καινοτόμων λειτουργιών. Συγκεκριμένα υποστηρίζει λειτουργία καλαθιού αγορών και παραγγελιών μέσω πιστωτικής κάρτας χρησιμοποιώντας ένα εικονικό σύστημα τραπεζικών συναλλαγών, πλήθος λειτουργιών αναζήτησης προϊόντων, διαφορετικά είδη προσωποποίησης, πολλαπλά επίπεδα ασφάλειας με χρήση κρυπτογράφησης, δημιουργία λογαριασμών χρηστών, forum κα. Στις καινοτομίες της εφαρμογής συγκαταλέγονται η χωρική αναζήτηση προϊόντων με χρήση Τ.Κ., η αναζήτηση αντίστοιχων τιμών σε άλλα καταστήματα και η social προσωποποίηση με χρήση βαρών στους παράγοντες προσωποποίησης. Ιδιαίτερη βαρύτητα έχει δοθεί επίσης στην συντηρησιμότητα του συστήματος και στη φιλικότητα προς τον χρήστη. Οι τεχνολογίες που χρησιμοποιήθηκαν είναι κατά κύριο λόγο HTML, CSS, PHP, Postgresql, smarty και λειτουργικό σύστημα Linux. / The purpose of this thesis is the development of a comprehensive online store that supports all functions of a modern e-shop plus a host of innovative features. Specifically, the application supports shopping cart, orders pipeline using a virtual banking system, many search products features, different kinds of personalization, multiple levels of security using encryption, user accounts, forum etc.. Innovations in the application include spatial search for products using postal codes, search for corresponding values in other e-shops and social personalization using weights to the personalization factors. Special attention was also given to the maintainability of the system and user friendliness. For the implementation of the application were used HTML, CSS, PHP, Postgresql, smarty and Linux operating system.

INTRODUÇÃO: A primeira doença humana atribuída à resistência hormonal foi o pseudo-hipoparatireoidismo (PHP), uma doença rara caracterizada por hipocalcemia, hiperfosfatemia e níveis elevados de hormônio paratireoidiano (PTH) na presença de função renal normal, quadro condizente com resistência ao PTH. A classificação original do PHP leva em consideração a osteodistrofia hereditária de Albright (AHO): presente no PHP1a e ausente no PHP1b. Na medida em que as bases moleculares do PHP têm sido compreendidas, uma classificação baseada no genótipo tem surgido. Segundo ela, pacientes com PHP1a apresentam mutações na região codificadora da Gsalfa do GNAS e o padrão de herança é autossômico dominante relacionado à transmissão materna. Por outro lado, o PHP1b é caracterizado por alterações nas regiões diferencialmente metiladas (DMRs) do GNAS por mecanismos não completamente esclarecidos, limitando a previsão do seu padrão de herança. Pacientes que apresentam a AHO na ausência de resistência hormonal têm o diagnóstico de pseudopseudo-hipoparatireoidismo (PPHP) e seu padrão de herança é autossômico dominante relacionado à transmissão paterna de mutações na região codificadora da Gsalfa do GNAS. OBJETIVOS: Classificar 25 pacientes com PHP com base em defeitos no GNAS e caracterizar seu fenótipo. Pesquisar mutações no GNAS nos quatro pacientes com PPHP e também caracterizar seu fenótipo. MÉTODOS: A avaliação fenotípica incluiu análise das resistências hormonais, pesquisa de repercussões crônicas da hipocalcemia/hiperfosfatemia (calcificações em sistema nervoso central: SNC e catarata) e identificação da AHO. A análise do GNAS foi feita por sequenciamento automático e MLPA (região codificadora da Gsalfa) e por MS-MLPA (região regulatória: DMRs). RESULTADOS: Resistência ao PTH foi identificada nos 25 pacientes com PHP e resistência ao TSH em 17/25. Calcificações em SNC e catarata estiveram presentes em 18 e 10 pacientes com PHP, respectivamente. A AHO foi caracterizada por: face arredondada (n=18), braquidactilia (n=11), baixa estatura (n=8), ossificações subcutâneas (n=6), obesidade (n=9) e retardo mental (n=3). Identificamos oito mutações (cinco novas) na região codificadora da Gsalfa em 10 pacientes com PHP1a e quatro pacientes com PPHP. Quinze pacientes apresentaram alteração no padrão de metilação das DMRs (genótipo: PHP1b). O fenótipo dos pacientes foi semelhante nos dois grupos. DISCUSSÃO E CONCLUSÃO: Nenhuma das classificações do PHP foi capaz de predizer gravidade ou o curso clínico da doença. Porém, o diagnóstico do PHP1a baseado no genótipo possibilitou a identificação precoce de uma paciente, a exclusão de PHP1a na filha de outra paciente e o aconselhamento genético em duas famílias. O diagnóstico de PHP1b em uma paciente só foi possível graças ao genótipo, visto que seu perfil laboratorial osteometabólico era inconclusivo. Com base no fenótipo, 8/15 pacientes com PHP1b seriam classificados como PHP1a considerando a presença de dois ou mais estigmas da AHO, podendo levar a falhas no aconselhamento genético. Portanto, concluímos que a classificação do PHP baseada na análise do GNAS é mais informativa do que a baseada no fenótipo, permitindo o diagnóstico precoce e o aconselhamento genético de casos familiais de PHP1a. A identificação do PHP1b deve ser promissora na medida em que seus mecanismos de transmissão forem mais bem entendidos / BACKGROUND: The first human disease attributed to hormone resistance was pseudohypoparathyroidism (PHP), a rare disease characterized by hypocalcemia, hyperphosphatemia and elevated parathyroid hormone (PTH) levels in the presence of normal renal function, consistent picture of PTH resistance. The original classification of PHP takes into account the Albright hereditary osteodystrophy (AHO): present in PHP1a and absent in PHP1b. As the molecular bases of PHP have been understood, a classification based on genotype has emerged. According to it, PHP1a patients present mutations in the Gsalpha coding region of the GNAS and the pattern of inheritance is autosomal dominant related to maternal transmission. On the other hand, PHP1b is characterized by alterations in differentially methylated regions (DMRs) of the GNAS by mechanisms not completely clear, limiting the prediction of the pattern of inheritance. Patients who present AHO in the absence of hormone resistance have the diagnosis of pseudopseudohypoparathyroidism (PPHP) and their pattern of inheritance is autosomal dominant related to paternal transmission of mutations in the Gsalfa coding region of the GNAS. OBJECTIVE: To classify 25 patients with PHP based on GNAS molecular defects and to characterize their phenotype. To search for GNAS mutations in four patients with PPHP and also to characterize their phenotype. METHODS: The phenotypic evaluation included analysis of hormone resistances, research of chronic repercussions of hypocalcemia/hyperphosphatemia (calcifications in central nervous system: CNS and cataract) and identification of AHO. The analysis of the GNAS was done by automated sequencing and MLPA (Gsalphaa coding region) and by MS-MLPA (regulatory region: DMRs). RESULTS: PTH resistance was identified in 25 patients with PHP and TSH resistance in 17/25. Calcifications in CNS and cataract were present in 18 and 10 patients with PHP, respectively. AHO was characterized by: rounded face (n=18), brachydactyly (n=11), short stature (n=8), subcutaneous ossifications (n=6), obesity (n=9) and mental retardation (n=3). We identified eight mutations (five novels) in the Gsalpha coding region in 10 patients with PHP1a. Fifteen patients presented alterations in the methylation pattern of DMRs (genotype: PHP1b). The phenotype of patients was similar in both groups. DISCUSSION AND CONCLUSION: None of the PHP classifications was able to predict the severity or clinical course of the disease. However, the diagnosis of PHP1a based on genotype allowed the early identification of one patient, the exclusion of PHP1a in the daughter of another patient and genetic counseling in two families. The PHP1b diagnosis in one patient was only possible due to the genotype, as her bone metabolism profile was inconclusive. Based on phenotype, 8/15 PHP1b patients would have been classified as PHP1a considering the presence of two or more AHO stigmas, being able to lead to failures in genetic counseling. Therefore, we conclude that the PHP classification based on GNAS analysis is more informative than that based on phenotype, allowing the early diagnosis and the genetic counseling for familial cases of PHP1a. The identification of PHP1b may be promising as its transmission mechanisms are better clarified

INTRODUÇÃO: A primeira doença humana atribuída à resistência hormonal foi o pseudo-hipoparatireoidismo (PHP), uma doença rara caracterizada por hipocalcemia, hiperfosfatemia e níveis elevados de hormônio paratireoidiano (PTH) na presença de função renal normal, quadro condizente com resistência ao PTH. A classificação original do PHP leva em consideração a osteodistrofia hereditária de Albright (AHO): presente no PHP1a e ausente no PHP1b. Na medida em que as bases moleculares do PHP têm sido compreendidas, uma classificação baseada no genótipo tem surgido. Segundo ela, pacientes com PHP1a apresentam mutações na região codificadora da Gsalfa do GNAS e o padrão de herança é autossômico dominante relacionado à transmissão materna. Por outro lado, o PHP1b é caracterizado por alterações nas regiões diferencialmente metiladas (DMRs) do GNAS por mecanismos não completamente esclarecidos, limitando a previsão do seu padrão de herança. Pacientes que apresentam a AHO na ausência de resistência hormonal têm o diagnóstico de pseudopseudo-hipoparatireoidismo (PPHP) e seu padrão de herança é autossômico dominante relacionado à transmissão paterna de mutações na região codificadora da Gsalfa do GNAS. OBJETIVOS: Classificar 25 pacientes com PHP com base em defeitos no GNAS e caracterizar seu fenótipo. Pesquisar mutações no GNAS nos quatro pacientes com PPHP e também caracterizar seu fenótipo. MÉTODOS: A avaliação fenotípica incluiu análise das resistências hormonais, pesquisa de repercussões crônicas da hipocalcemia/hiperfosfatemia (calcificações em sistema nervoso central: SNC e catarata) e identificação da AHO. A análise do GNAS foi feita por sequenciamento automático e MLPA (região codificadora da Gsalfa) e por MS-MLPA (região regulatória: DMRs). RESULTADOS: Resistência ao PTH foi identificada nos 25 pacientes com PHP e resistência ao TSH em 17/25. Calcificações em SNC e catarata estiveram presentes em 18 e 10 pacientes com PHP, respectivamente. A AHO foi caracterizada por: face arredondada (n=18), braquidactilia (n=11), baixa estatura (n=8), ossificações subcutâneas (n=6), obesidade (n=9) e retardo mental (n=3). Identificamos oito mutações (cinco novas) na região codificadora da Gsalfa em 10 pacientes com PHP1a e quatro pacientes com PPHP. Quinze pacientes apresentaram alteração no padrão de metilação das DMRs (genótipo: PHP1b). O fenótipo dos pacientes foi semelhante nos dois grupos. DISCUSSÃO E CONCLUSÃO: Nenhuma das classificações do PHP foi capaz de predizer gravidade ou o curso clínico da doença. Porém, o diagnóstico do PHP1a baseado no genótipo possibilitou a identificação precoce de uma paciente, a exclusão de PHP1a na filha de outra paciente e o aconselhamento genético em duas famílias. O diagnóstico de PHP1b em uma paciente só foi possível graças ao genótipo, visto que seu perfil laboratorial osteometabólico era inconclusivo. Com base no fenótipo, 8/15 pacientes com PHP1b seriam classificados como PHP1a considerando a presença de dois ou mais estigmas da AHO, podendo levar a falhas no aconselhamento genético. Portanto, concluímos que a classificação do PHP baseada na análise do GNAS é mais informativa do que a baseada no fenótipo, permitindo o diagnóstico precoce e o aconselhamento genético de casos familiais de PHP1a. A identificação do PHP1b deve ser promissora na medida em que seus mecanismos de transmissão forem mais bem entendidos / BACKGROUND: The first human disease attributed to hormone resistance was pseudohypoparathyroidism (PHP), a rare disease characterized by hypocalcemia, hyperphosphatemia and elevated parathyroid hormone (PTH) levels in the presence of normal renal function, consistent picture of PTH resistance. The original classification of PHP takes into account the Albright hereditary osteodystrophy (AHO): present in PHP1a and absent in PHP1b. As the molecular bases of PHP have been understood, a classification based on genotype has emerged. According to it, PHP1a patients present mutations in the Gsalpha coding region of the GNAS and the pattern of inheritance is autosomal dominant related to maternal transmission. On the other hand, PHP1b is characterized by alterations in differentially methylated regions (DMRs) of the GNAS by mechanisms not completely clear, limiting the prediction of the pattern of inheritance. Patients who present AHO in the absence of hormone resistance have the diagnosis of pseudopseudohypoparathyroidism (PPHP) and their pattern of inheritance is autosomal dominant related to paternal transmission of mutations in the Gsalfa coding region of the GNAS. OBJECTIVE: To classify 25 patients with PHP based on GNAS molecular defects and to characterize their phenotype. To search for GNAS mutations in four patients with PPHP and also to characterize their phenotype. METHODS: The phenotypic evaluation included analysis of hormone resistances, research of chronic repercussions of hypocalcemia/hyperphosphatemia (calcifications in central nervous system: CNS and cataract) and identification of AHO. The analysis of the GNAS was done by automated sequencing and MLPA (Gsalphaa coding region) and by MS-MLPA (regulatory region: DMRs). RESULTS: PTH resistance was identified in 25 patients with PHP and TSH resistance in 17/25. Calcifications in CNS and cataract were present in 18 and 10 patients with PHP, respectively. AHO was characterized by: rounded face (n=18), brachydactyly (n=11), short stature (n=8), subcutaneous ossifications (n=6), obesity (n=9) and mental retardation (n=3). We identified eight mutations (five novels) in the Gsalpha coding region in 10 patients with PHP1a. Fifteen patients presented alterations in the methylation pattern of DMRs (genotype: PHP1b). The phenotype of patients was similar in both groups. DISCUSSION AND CONCLUSION: None of the PHP classifications was able to predict the severity or clinical course of the disease. However, the diagnosis of PHP1a based on genotype allowed the early identification of one patient, the exclusion of PHP1a in the daughter of another patient and genetic counseling in two families. The PHP1b diagnosis in one patient was only possible due to the genotype, as her bone metabolism profile was inconclusive. Based on phenotype, 8/15 PHP1b patients would have been classified as PHP1a considering the presence of two or more AHO stigmas, being able to lead to failures in genetic counseling. Therefore, we conclude that the PHP classification based on GNAS analysis is more informative than that based on phenotype, allowing the early diagnosis and the genetic counseling for familial cases of PHP1a. The identification of PHP1b may be promising as its transmission mechanisms are better clarified

The last couple of years the use of Internet has changed in the way that the web pages can be affected of the person that uses them. Because of this dynamic Internet technology has emerged that makes it possible for a web page to receive information from a web browser. This information can then be used to affect the appearance of the page. PHP and ASP are two dynamic Internet technologies. They are integrated in HTML and are executed on the web server. E-commerce and search pages are example of this kind of web pages. The purpose of this examine thesis is to find out which of the technologies that are best suited when information needs to be stored on the web server. The thesis turns mostly to programmers that are planning to create a web application for this purpose. The analysis, which consists of three main questions, is based on a literature study and on a web application that has been developed. The result of the analysis is that ASP is more complicated because more external components are included and a lot of objects has to be created. PHP is a much more structured technology and is simpler constructed. Our conclusion of this thesis is that the functionality within both technologies are basically the same. But because PHP´s code is constructed much simpler this technology is more suited for storing. De senaste åren har användningen av Internet ändrats på så sätt att webbsidor ska kunna påverkas av den som använder sig av dem. Därför har något som kallas dynamisk webbhantering skapats, vilket gör det möjligt för en webbsida att ta emot information från en webbläsare. PHP och ASP är två teknologier inom dynamisk webbhantering. De integreras i HTML-kod och exekveras på webbservern. Exempel på sådana sidor är e-handelsidor och söksidor. Detta examensarbete har gjorts för att ta reda på vilken av teknologierna som passar bäst när lagring av data på webbservern krävs. Arbetet vänder sig främst till programmerare som planerar att skapa en webbapplikation för detta ändamål. Analys har gjorts utifrån en frågeställning baserad på litteraturstudier och på programmering av en minde webbapplikation. Resultatet av analysen är att ASP, i just de frågor vi tagit upp, är mer komplicerat då externa komponenter blandas in och många objekt måste skapas. PHP är mycket mer strukturerat och enklare uppbyggt. Vår slutsats av arbetet är att funktionaliteten hos de båda teknologierna i stort sett är den samma, men på grund av att PHP är enklare kodningsmässigt sett är det denna teknologi som är bäst lämpad vid datalagring.

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Proefschrift Universiteit van Amsterdam. / Met samenvatting in het Nederlands.

Proefschrift Universiteit Twente, Enschede. / Lit. opg.: p. [153]-158. - Met een samenvatting in het Nederlands.

Proefschrift Universiteit Maastricht. / Met index, lit. opg. - Met samenvatting in het Nederlands.